The San Francisco 49ers visit the Seattle Seahawks on Sunday, October 11, 2026, for a Week 5 meeting between two of the NFC’s strongest early-season teams. San Francisco arrives undefeated at 4–0, while Seattle is 3–1, giving this divisional matchup immediate significance even with most of the schedule still ahead.
Game Details
- Date: Sunday, October 11, 2026
- Kickoff: 4:25 p.m. Eastern / 1:25 p.m. Pacific
- Venue: Lumen Field, Seattle
- Broadcast: FOX
The date, kickoff time and venue are listed on the NFL’s Seahawks schedule.
Injuries and Player Availability
San Francisco will be without defensive end Nick Bosa, fullback Kyle Juszczyk and safety Marques Sigle. All three are listed as out on the official team injury report. Bosa’s absence is especially important because it removes a central piece of the 49ers’ pass rush before a road divisional game.
Other San Francisco players appeared on the report without a confirmed final game designation in the supplied information. That group includes running back Christian McCaffrey, who was listed for rest, wide receiver Mike Evans with a rib issue and linebacker Jaden Dugger, who was a full participant despite a shoulder listing. Those entries should not be treated as confirmed absences, but their availability must remain uncertain until a final designation is reported.
Seattle has three confirmed absences: running back Zach Charbonnet, cornerback Julian Neal and linebacker Chazz Surratt. Charbonnet is out with a knee injury, narrowing the Seahawks’ backfield options. Wide receiver Irvin Charles, running back George Holani, cornerback Upton Stout and defensive end Mykel Williams are listed as questionable.
Matchup Factors
San Francisco’s Success at Lumen Field
Seattle normally expects Lumen Field to work in its favor, particularly against a division opponent. Recent history complicates that assumption. The 49ers have won four consecutive regular-season games against the Seahawks at Lumen Field, according to the 49ers’ 2026 schedule announcement.
That streak does not decide Sunday’s result, but it shows San Francisco has repeatedly handled the challenges of playing in Seattle. Crowd noise, communication and game management remain important, yet the setting should not be unfamiliar or intimidating to a 49ers team carrying a 4–0 record into Week 5.
The Missing Stars Affect Different Areas
Bosa and Charbonnet play different roles, but both absences could alter how the teams approach the game. Without Bosa, San Francisco must find another way to create pressure and prevent Seattle’s offense from operating comfortably. If the 49ers cannot disrupt passing situations, the Seahawks could sustain drives and make their home-field advantage more meaningful.
Seattle’s loss of Charbonnet creates a separate challenge. The Seahawks have one fewer established backfield option available, and George Holani’s questionable designation adds more uncertainty at the position. San Francisco may be able to devote greater attention to Seattle’s passing game, although Bosa’s absence makes executing that plan more difficult.
San Francisco’s Unbeaten Start vs. Seattle’s Response
The 49ers’ four victories have come at the Rams and at home against the Dolphins, Cardinals and Broncos. Seattle has beaten the Patriots, Cardinals and Chargers while losing on the road to the Commanders, according to the available game results.
Both records are strong, but San Francisco has been more consistent through four games. Seattle’s best response is likely to be turning the contest into a physical divisional game in which home field, defensive stops and a few high-leverage plays matter more than overall form.
Prediction
Pick: 49ers to win.
San Francisco’s unbeaten start and four-game regular-season winning streak at Lumen Field provide the clearest basis for the choice. The 49ers have shown they can win in this venue, and their 4–0 opening gives them a slight edge over a Seattle team that has already taken one road loss.
The strongest reason this prediction could be wrong is Bosa’s absence. If Seattle protects well and controls the game without Charbonnet, San Francisco may struggle to generate enough pressure to get off the field. Add Seattle’s home crowd and a 3–1 record, and the Seahawks have a credible path to ending the 49ers’ run at Lumen Field. Still, based on the confirmed information available, San Francisco is the narrower choice in what should be a competitive divisional matchup.
