The Philadelphia Eagles and Jacksonville Jaguars meet Sunday, October 11, 2026, in a Week 5 matchup in London. Jacksonville arrives at 3-1 and atop the AFC South, while Philadelphia is 2-2 after consecutive losses. Injuries and major offensive-line turnover leave the Eagles facing a difficult assignment against one of the NFL’s strongest early-season defenses.
Game Details
- Date: Sunday, October 11, 2026
- Kickoff: 9:30 a.m. EDT, 1:30 p.m. UTC and 2:30 p.m. BST
- Venue: Tottenham Hotspur Stadium, London, United Kingdom
- Designated home team: Jacksonville Jaguars
- Broadcast: NFL Network nationally and FOX30 in Jacksonville
The date, kickoff time and venue are listed by the NFL game center and the official Jaguars game page.
Latest Verified Odds
The latest explicitly timestamped prices in the research were from DraftKings Sportsbook via the BALLDONTLIE feed, updated October 10 at 4:16 p.m. ET:
- Moneyline: Eagles +320; Jaguars -410
- Point spread: Eagles +7.5 (-112); Jaguars -7.5 (-108)
- Total: Over 41.5 (-112); Under 41.5 (-108)
Those figures came from the timestamped Eagles odds page. A direct DraftKings snapshot also showed a 7.5-point spread and a 41.5 total, although its moneyline was from an earlier, untimestamped price. Odds can change before kickoff, so bettors should verify the current market.
Injuries and Player Availability
Philadelphia’s absences are concentrated around its offense. Running back Saquon Barkley, wide receivers DeVonta Smith and Marquise Brown, safety Marcus Epps and center/guard Drew Kendall have been ruled out. Running back Tank Bigsby is already on injured reserve, leaving Will Shipley expected to handle the primary backfield role, supported by Dameon Pierce and Carson Steele.
There is better news at quarterback and tight end. Jalen Hurts is available after practicing fully Friday despite being added to the report with a calf issue. Dallas Goedert is expected to return after missing two games with a knee injury, while linebacker Zack Baun and tackle Fred Johnson have also been cleared. Outside linebacker Jonathan Greenard is questionable with an ankle injury after missing practice throughout the week. The statuses are detailed in the official Eagles injury report.
Jacksonville has ruled out cornerback Jaylon Jones with a hamstring injury. Safety Eric Murray is doubtful because of a concussion, although he progressed to limited practices Thursday and Friday. Several other Jaguars, including Josh Hines-Allen, Jourdan Lewis and Anton Harrison, carry no final game designation. Jacksonville elevated cornerback Jabbar Muhammad and safety Kaevon Merriweather on Saturday, adding depth to a banged-up secondary. See the official Jaguars injury report and Saturday roster moves.
Official game-day inactive lists were not available by the October 10 research cutoff, so the availability of questionable and doubtful players still requires final confirmation.
Matchup Factors
Jacksonville’s Front Against a Rebuilt Eagles Line
The Jaguars generated 41 quarterback pressures without blitzing through four games, tied for fifth in the league. Philadelphia, meanwhile, had already conceded 12 sacks and a 43.2% pressure rate before an unusually disruptive week: right tackle Lane Johnson retired Tuesday, Cam Jurgens was traded Wednesday and Kendall was ruled out. The projected line now includes several inexperienced or newly installed starters. That mismatch could prevent Hurts from testing Jacksonville’s vulnerable secondary.
Philadelphia’s Missing Playmakers
The Eagles must replace Barkley, Smith and Brown against a defense allowing 74.3 rushing yards and 13.3 points per game. Jacksonville has also surrendered touchdowns on only four of 14 opponent red-zone trips and has held every opponent to 20 points or fewer. Goedert’s return helps, but Philadelphia’s available personnel make sustaining drives difficult—especially after the Eagles went 0-for-12 on third down in their 24-20 loss to the Rams.
The Jaguars’ Secondary Is the Opening
Jacksonville’s overall defensive results are excellent, including eight takeaways, but it ranks 31st in passing yards allowed per game. Jones is out, Murray is doubtful and other defensive backs dealt with injuries during the week. If Philadelphia’s line gives Hurts enough time, the Eagles can challenge that unit. The obstacle is doing so without Smith and Brown while avoiding the pressure and turnovers that have fueled Jacksonville’s 3-1 start.
Prediction
Pick: Jaguars to win. Jacksonville has the more stable lineup, the stronger recent form and the defensive front best positioned to control this particular matchup. Philadelphia’s simultaneous losses at running back, receiver and along the offensive line are difficult to overcome against a defense that has kept every opponent at 20 points or fewer.
The strongest reason this prediction could be wrong is Jacksonville’s pass defense. Its No. 31 ranking in passing yards allowed, combined with injuries in the secondary, gives Hurts a clear route to an upset if the reconstructed offensive line holds up. Still, Jacksonville’s ability to create pressure without blitzing makes that protection difficult to trust.